Compounding Flashcards

Which beyond-use date (BUD) applies to a non-aqueous compounded preparation stored at room temperature?

Answer: 6 months or the earliest manufacturer expiration date, whichever is sooner

USP assigns non-aqueous formulations a BUD of 6 months or the earliest component expiration, whichever comes first.

What is the primary purpose of a levigating agent in ointment preparation?

Answer: To reduce particle size and improve uniform distribution of the active ingredient

Levigating agents (e.g., mineral oil, glycerin) wet and reduce powder particle size before incorporation into an ointment base.

A pharmacy technician is preparing a 2% hydrocortisone cream using a 10% hydrocortisone cream and a plain cream base. What compounding method is being used?

Answer: Geometric dilution

Geometric dilution involves progressively adding and mixing equal amounts of base to a potent ingredient to ensure uniform distribution.

Which USP chapter governs sterile compounding quality standards for pharmacy-prepared products?

Answer: USP

USP sets the standards for sterile compounding including environmental monitoring, BUDs, and personnel training.

When compounding a suppository using the fusion method, which step is critical to prevent sedimentation of the active drug?

Answer: Continuously stirring the mixture until it congeals

Continuous stirring until congealing keeps the active ingredient evenly suspended throughout the suppository base.

Which type of water is required for sterile compounding preparations?

Answer: Sterile Water for Injection (SWFI)

SWFI meets USP standards for pyrogen limits and sterility required in sterile compounding.

A compounded preparation's label must include all of the following EXCEPT:

Answer: The prescriber's DEA number

The DEA number is not a required label element for compounded preparations unless the preparation is a controlled substance prescription.