PTCB Pharmacology #2 3

Question 1

Which of the following best describes a drug's "half-life"?

Accepted Answer

Time required for the plasma drug concentration to decrease by 50%

Answer

Time for the drug to reach maximum concentration

Answer

Duration of drug effect after a single dose

Answer

Time for the drug to begin working

Question 2

Fluoroquinolone antibiotics (e.g., ciprofloxacin) work by:

Accepted Answer

Inhibiting DNA gyrase and topoisomerase IV

Answer

Inhibiting cell wall synthesis

Answer

Inhibiting protein synthesis at the 30S ribosome

Answer

Disrupting bacterial cell membrane integrity

Question 3

A drug's "volume of distribution" (Vd) indicates:

Accepted Answer

The extent to which the drug distributes throughout the body relative to plasma

Answer

How quickly the drug is eliminated from the body

Answer

The rate at which the drug crosses the blood-brain barrier

Answer

The percentage of drug bound to plasma proteins

Question 4

Which of the following is a tetracycline antibiotic?

Accepted Answer

Doxycycline

Answer

Azithromycin

Answer

Amoxicillin

Answer

Clindamycin

Question 5

Which of the following drug classes are typically used as "rescue" medications for acute asthma attacks?

Accepted Answer

Short-acting beta-agonists (SABA)

Answer

Inhaled corticosteroids (ICS)

Answer

Long-acting beta-agonists (LABA)

Answer

Leukotriene receptor antagonists

Question 6

Macrolide antibiotics (e.g., azithromycin) work by:

Accepted Answer

Inhibiting protein synthesis by binding the 50S ribosomal subunit

Answer

Inhibiting cell wall synthesis

Answer

Disrupting the bacterial cell membrane

Answer

Inhibiting DNA gyrase