Rifampicin is a potent inducer of CYP3A4. A patient on long-term warfarin starts rifampicin for tuberculosis. What is the most likely clinical consequence?
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A
Increased INR due to higher warfarin levels
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B
No change in INR
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C
Decreased INR due to increased warfarin metabolism
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D
Increased risk of warfarin-induced hepatotoxicity