PSA Adverse Drug Reactions 2

Question 1

Which classification system uses letters A through F to categorize adverse drug reactions by mechanism and predictability?

Accepted Answer

Rawlins-Thompson classification

Answer

The Rawlins-Thompson classification categorizes ADRs as Type A (augmented, dose-dependent) through Type F, describing mechanism and predictability.

Question 2

A patient develops widespread blistering with mucosal involvement and epidermal detachment affecting >30% of BSA after starting allopurinol. What is the most likely diagnosis?

Accepted Answer

Toxic epidermal necrolysis

Answer

Toxic epidermal necrolysis is defined by epidermal detachment affecting >30% of body surface area and is a life-threatening ADR most commonly triggered by allopurinol, sulfonamides, or anticonvulsants.

Question 3

A patient develops serotonin syndrome after starting tramadol while already prescribed sertraline. Which symptom triad is most characteristic?

Accepted Answer

Agitation, hyperthermia, and clonus

Answer

Serotonin syndrome presents with the classic triad of neuromuscular excitability (clonus, hyperreflexia), autonomic instability, and altered mental status including agitation and hyperthermia.

Question 4

Which of the following drugs is LEAST likely to cause QTc interval prolongation?

Accepted Answer

Metformin

Answer

Metformin does not affect cardiac ion channels; QT-prolonging drugs include macrolide antibiotics, antipsychotics, and antiarrhythmics that block cardiac hERG potassium channels.

Question 5

A patient on isoniazid for tuberculosis develops jaundice and ALT 10 times the upper limit of normal. What pattern of drug-induced liver injury is this?

Accepted Answer

Hepatocellular hepatotoxicity

Answer

Isoniazid causes predominantly hepatocellular injury with markedly elevated ALT; it can progress to fulminant hepatic failure if not discontinued promptly upon recognition.

(PSA) Prescribing Safety Assessment Practice Test

(PSA) Prescribing Safety Assessment Practice Test

PSA Adverse Drug Reactions 2