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Psychopharmacology Flashcards

7 cards from real PMH-C practice questions. Tap to flip, then mark Knew It or Still Learning โ€” missed cards come back until you master them.

Read the first 7 Psychopharmacology flashcards as text
  1. Neonatal adaptation syndrome (NAS) following SSRI exposure near delivery most commonly includes which cluster of symptoms?

    Answer: Jitteriness, irritability, feeding difficulties, and respiratory distress

    NAS from SSRIs presents with jitteriness, irritability, feeding difficulties, and mild respiratory distress, typically self-resolving within days.

  2. Which factor most significantly increases the risk of postpartum psychosis in a patient with bipolar disorder?

    Answer: Abrupt discontinuation of mood stabilizer peripartum

    Abrupt discontinuation of mood stabilizers peripartum substantially increases relapse risk, particularly postpartum psychosis in bipolar disorder.

  3. A pregnant patient with schizophrenia requires antipsychotic medication. Which risk is most associated with first-generation antipsychotics in pregnancy?

    Answer: Neonatal extrapyramidal symptoms and withdrawal

    First-generation antipsychotics, especially haloperidol near delivery, are associated with neonatal extrapyramidal symptoms and withdrawal.

  4. Why is lamotrigine dosing particularly complex during pregnancy?

    Answer: Estrogen strongly induces glucuronidation, reducing lamotrigine serum levels

    Elevated estrogen during pregnancy induces UGT enzymes that glucuronidate lamotrigine, reducing serum levels by up to 50-65% and requiring dose increases.

  5. A patient on bupropion for depression wants to conceive. What perinatal consideration is most critical to discuss?

    Answer: Some studies suggest a possible small increased risk of cardiac defects and miscarriage

    Some studies suggest a small increased risk of congenital cardiac defects and spontaneous abortion with bupropion, though evidence is mixed and absolute risks remain low.

  6. Which psychotropic medication requires monitoring of maternal serum levels each trimester due to significant pharmacokinetic changes in pregnancy?

    Answer: Lithium

    Lithium clearance increases significantly during pregnancy due to increased GFR, requiring regular serum level monitoring and dose adjustments.

  7. Persistent pulmonary hypertension of the newborn (PPHN) has been associated with which exposure in the third trimester?

    Answer: SSRIs

    Late-pregnancy SSRI exposure has been associated with a small increased risk of PPHN, though absolute risk remains low and benefits often outweigh risks.