PLAB 2 Prescribing Safety & Emergency Management

Question 1

A patient in the Emergency Department is found unresponsive. What is the most appropriate immediate action according to the UK Resuscitation Council guidelines?

Accepted Answer

Shout for help, check for danger, check for response, open airway (head tilt-chin lift), check for breathing (look, listen, feel for 10 seconds), call the resuscitation team and start CPR (30:2) if not breathing normally

Answer

The UK Resuscitation Council Adult ALS algorithm begins with the basic life support sequence: check safety, check responsiveness, shout for help, open airway, look for normal breathing for no more than 10 seconds, call the resuscitation team (or ask someone to), then start CPR at 30 compressions to 2 breaths at a rate of 100–120/min.

Question 2

During a medical emergency, a patient has anaphylaxis following an antibiotic injection. What is the first-line treatment and route of administration?

Accepted Answer

IM adrenaline 0.5mg (1:1000) into the anterolateral thigh

Answer

Adrenaline (epinephrine) 0.5mg IM (1:1000 solution = 0.5ml) into the anterolateral thigh is the life-saving first-line treatment for anaphylaxis. IM injection into the thigh provides faster and more reliable absorption than subcutaneous administration. IV adrenaline is only for use by specialists in specific circumstances. Antihistamines and steroids are adjunctive, not first-line.

Question 3

When prescribing in a hospital setting, which five components are essential for a valid drug prescription?

Accepted Answer

Drug name (generic), dose (in approved units), route, frequency/timing, prescriber's signature and date, and the patient's name/date of birth/hospital number on the drug chart

Answer

A valid hospital prescription must include: patient identifiers (name, DOB, hospital number); drug name (generic); dose with units; route of administration; frequency/timing; start date; prescriber signature and name (printed). Incomplete prescriptions are a common source of medication errors and should not be dispensed without clarification.

Question 4

A patient on a surgical ward develops acute confusion, fever (38.8°C), hypotension (BP 90/60), and tachycardia (HR 115 bpm) on post-operative day 2. What is the most important immediate action?

Accepted Answer

Perform a full sepsis assessment (NEWS score), take blood cultures and other sepsis screen, and start the Sepsis Six bundle within one hour

Answer

This patient has signs of sepsis (suspected infection + organ dysfunction indicators: confusion, hypotension). The National Early Warning Score (NEWS2) should be calculated. The Sepsis Six bundle must be initiated within one hour: oxygen, blood cultures, IV antibiotics, IV fluids (if hypotensive), measure lactate, catheterise and monitor urine output. Early treatment reduces mortality.

Question 5

A patient's medication chart shows they are prescribed lithium. Which monitoring parameters are essential?

Accepted Answer

Serum lithium level (12 hours post dose), renal function (eGFR, urine output), thyroid function, calcium — all regularly; serum level kept in narrow therapeutic range (0.4–1.0 mmol/L for maintenance)

Answer

Lithium has a narrow therapeutic index. Toxicity (>1.5 mmol/L) causes tremor, confusion, nausea, and cardiac arrhythmias. Monitoring: serum lithium level (12 hours post-dose, every 3–6 months when stable); U&E (lithium is renally excreted, renal impairment raises levels); thyroid (lithium causes hypothyroidism); calcium (hypercalcaemia). Dehydration and NSAIDs raise levels.

PLAB 2 Practice Test

PLAB 2 Practice Test

PLAB 2 Prescribing Safety & Emergency Management