PLAB 2 Acute Management 2

Question 1

A patient on the ward develops a tonic-clonic seizure that has lasted 7 minutes. According to NICE epilepsy guidelines, what is the first-line treatment for status epilepticus?

Accepted Answer

IV lorazepam 4 mg (or buccal midazolam 10 mg if no IV access), repeated once after 10 minutes if seizure continues

Answer

Status epilepticus is defined as a seizure lasting >5 minutes (or recurrent seizures without recovery). First-line treatment is IV lorazepam 4 mg (repeated once after 10 minutes) or buccal midazolam if no IV access. If seizures continue, second-line options include IV phenytoin or IV levetiracetam.

Question 2

A 60-year-old man presents to A&E with a 4-hour history of severe tearing chest pain radiating to the back, and asymmetric blood pressure readings in both arms. What is the most likely diagnosis and most appropriate urgent investigation?

Accepted Answer

Aortic dissection — perform urgent CT angiography of the aorta

Answer

Sudden severe tearing chest pain radiating to the back with blood pressure asymmetry between arms is classic for aortic dissection. CT aortography is the investigation of choice. Type A (ascending aorta) requires emergency surgery. Type B (descending) is usually managed medically with IV labetalol to reduce shear stress.

Question 3

A patient presents to A&E with pleuritic chest pain, tachycardia, and haemoptysis 10 days after a long-haul flight. Their Wells score is 7. What is the most appropriate next investigation?

Accepted Answer

CT pulmonary angiography (CTPA) — as the Wells score >4 indicates PE is likely, CTPA is the first-line imaging investigation

Answer

A Wells score >4 indicates PE is likely, and NICE recommends proceeding directly to CTPA without D-dimer (D-dimer is used when Wells score ≤4). Interim treatment with anticoagulation (LMWH or DOAC) should be started while awaiting imaging if PE is clinically likely.

Question 4

A patient on a medical ward develops a NEWS2 score of 9 with a respiratory rate of 30, SpO2 of 88% on air, heart rate of 125, systolic BP of 85 mmHg, and new confusion. What is the appropriate escalation?

Accepted Answer

This constitutes a medical emergency — immediately call the critical care outreach team or cardiac arrest team, commence ABCDE assessment, and consider ICU admission

Answer

A NEWS2 score ≥7 is a red score indicating a clinical emergency. RCP guidelines require an urgent or emergency response — immediate clinical assessment using ABCDE, critical care outreach or medical emergency team review, and consideration of ICU transfer. Do not delay escalation.

Question 5

A patient presents with a GCS of 3 and is in cardiac arrest with a shockable rhythm (ventricular fibrillation). According to UK Resuscitation Council guidelines, what is the correct sequence?

Accepted Answer

Deliver a shock immediately, then commence 2 minutes of CPR (30:2 ratio), reassess rhythm, give adrenaline 1 mg IV after the third shock, then amiodarone 300 mg IV after the third shock

Answer

For shockable rhythms (VF/pulseless VT): deliver a shock immediately, then 2 minutes of CPR. Adrenaline 1 mg IV is given after the third shock (then every 3-5 minutes). Amiodarone 300 mg IV is also given after the third shock. The cycle continues: shock → 2 min CPR → reassess.

PLAB 2 Practice Test

PLAB 2 Practice Test

PLAB 2 Acute Management 2