Pharmacy Pharmaceutical Chemistry 2

Question 1

Which functional group is responsible for the acidic character of aspirin (acetylsalicylic acid)?

Accepted Answer

Carboxylic acid group

Answer

Ester group

Answer

Hydroxyl group

Answer

Carbonyl group

Question 2

The Henderson-Hasselbalch equation is primarily used in pharmacy to:

Accepted Answer

Calculate the ratio of ionized to unionized drug forms at a given pH

Answer

Predict drug metabolism rates

Answer

Determine drug solubility in lipids

Answer

Measure drug receptor binding affinity

Question 3

Which stereochemical descriptor system is used to unambiguously name chiral centers in drug molecules?

Accepted Answer

R/S (Cahn-Ingold-Prelog) system

Answer

D/L system

Answer

+/- optical rotation system

Answer

cis/trans system

Question 4

Prodrugs are compounds that:

Accepted Answer

Require biotransformation in the body to become active

Answer

Are pharmacologically active as administered

Answer

Have shorter half-lives than parent drugs

Answer

Cannot cross the blood-brain barrier

Question 5

What is the primary mechanism by which beta-lactam antibiotics exert their antibacterial effect?

Accepted Answer

Inhibiting bacterial cell wall transpeptidase (PBPs)

Answer

Inhibiting bacterial DNA gyrase

Answer

Disrupting the bacterial cell membrane

Answer

Inhibiting bacterial protein synthesis at the 30S ribosome

Question 6

Optical rotation is measured using a:

Accepted Answer

Polarimeter

Answer

Spectrophotometer

Answer

Refractometer

Answer

Viscometer

Question 7

Which type of isomerism involves compounds with the same molecular formula but different spatial arrangements that are non-superimposable mirror images?

Accepted Answer

Enantiomerism

Answer

Constitutional isomerism

Answer

Geometric isomerism

Answer

Conformational isomerism