Pharmacy Drug Delivery Systems 5

Question 1

Which nasal drug delivery feature allows direct drug transport to the brain, bypassing the blood-brain barrier?

Accepted Answer

Nose-to-brain pathway via olfactory neurons

Answer

Mucociliary clearance

Answer

Hepatic first-pass metabolism

Answer

Pulmonary absorption

Question 2

A matrix tablet formulated with HPMC releases drug by:

Accepted Answer

Erosion and diffusion through a gel layer

Answer

Osmotic pumping

Answer

pH-triggered membrane rupture

Answer

Enzymatic degradation

Question 3

For a drug to be suitable for pulmonary delivery to the deep lung, the aerodynamic particle size should be:

Accepted Answer

1–5 µm

Answer

10–100 µm

Answer

>100 µm

Answer

0.01–0.1 µm

Question 4

Which statement about microemulsions is TRUE?

Accepted Answer

They are thermodynamically stable, clear systems with droplet size 10–100 nm

Answer

They are thermodynamically unstable systems

Answer

They are optically opaque formulations

Answer

They require high-energy homogenization to form

Question 5

An implantable drug delivery device made of ethylene-vinyl acetate (EVA) releases drug by:

Accepted Answer

Diffusion through the non-degradable polymer matrix

Answer

Polymer degradation

Answer

Osmosis

Answer

Enzymatic cleavage

Question 6

The concept of 'stealth liposomes' refers to liposomes coated with PEG to:

Accepted Answer

Prolong circulation time by avoiding phagocytic uptake

Answer

Increase drug loading efficiency

Answer

Target liver macrophages specifically

Answer

Increase drug release rate

Question 7

Which dissolution test apparatus is MOST appropriate for evaluating drug release from a transdermal patch?

Accepted Answer

USP Apparatus 5 (paddle over disk) or 6 (cylinder)

Answer

USP Apparatus 1 (basket)

Answer

USP Apparatus 2 (paddle)

Answer

USP Apparatus 4 (flow-through cell)