Pharmacy Drug Delivery Systems 4

Question 1

Ophthalmic solutions must be sterile AND typically buffered to a pH of approximately:

Accepted Answer

7.4

Answer

4.0–4.5

Answer

9.0–10.0

Answer

2.0–3.0

Question 2

A drug with a narrow therapeutic index is BEST suited for which delivery strategy?

Accepted Answer

Extended-release formulation to minimize peak-trough fluctuation

Answer

Immediate-release tablet taken once daily

Answer

Bulk powder in a capsule

Answer

Rapidly dissolving sublingual strip

Question 3

The rate-limiting step in drug release from a reservoir-type transdermal system is:

Accepted Answer

The rate-controlling membrane

Answer

Drug dissolution in the reservoir

Answer

Stratum corneum permeation

Answer

Systemic distribution

Question 4

Cyclodextrins improve drug delivery primarily by:

Accepted Answer

Complexing drugs in their hydrophobic cavity to increase solubility

Answer

Forming covalent bonds with the drug

Answer

Acting as disintegrants

Answer

Lowering the melting point of lipid excipients

Question 5

Which of the following is a characteristic of a Class II BCS drug?

Accepted Answer

Low solubility, high permeability

Answer

High solubility, high permeability

Answer

High solubility, low permeability

Answer

Low solubility, low permeability

Question 6

Pegylation of a nanoparticle drug carrier is done PRIMARILY to:

Accepted Answer

Evade opsonization and extend circulation time

Answer

Increase drug loading capacity

Answer

Target specific receptors

Answer

Improve oral absorption

Question 7

A rectal suppository base melts at body temperature; this type of base is classified as:

Accepted Answer

Fatty (oleaginous) base such as cocoa butter

Answer

Hydrophilic (water-soluble) base

Answer

Emulsifying base

Answer

Absorption base