Pharmacy Drug Delivery Systems 3

Question 1

Enteric coating on a tablet is designed to dissolve at:

Accepted Answer

pH above 5.5–6 (small intestine)

Answer

pH 1–2 (stomach)

Answer

pH 7.4 (blood)

Answer

pH 8–9 (colon)

Question 2

Which inhalation device requires the patient to generate sufficient inspiratory flow to disperse the drug?

Accepted Answer

Dry powder inhaler (DPI)

Answer

Pressurized metered-dose inhaler (pMDI)

Answer

Nebulizer

Answer

Soft mist inhaler

Question 3

In parenteral formulations, isotonicity is adjusted to match blood osmolarity of approximately:

Accepted Answer

308 mOsm/kg

Answer

150 mOsm/kg

Answer

500 mOsm/kg

Answer

100 mOsm/kg

Question 4

A prodrug is a pharmacologically inactive compound that:

Accepted Answer

Is converted in vivo to an active drug

Answer

Is stored in fat tissue until released

Answer

Binds irreversibly to plasma proteins

Answer

Forms a chelate with metal ions

Question 5

Which property of a drug MOST favors absorption via the buccal or sublingual route?

Accepted Answer

High lipophilicity and low ionization at oral pH

Answer

High molecular weight (>1000 Da)

Answer

Poor membrane permeability

Answer

Complete first-pass extraction

Question 6

The term 'depot injection' refers to a formulation that:

Accepted Answer

Creates a drug reservoir at the injection site for prolonged release

Answer

Must be injected into a vein

Answer

Dissolves immediately upon injection

Answer

Requires reconstitution before every dose

Question 7

Which polymer is used in PLGA microspheres to control drug release by biodegradation?

Accepted Answer

Poly(lactic-co-glycolic acid)

Answer

Polyethylene glycol (PEG)

Answer

Hydroxypropyl methylcellulose (HPMC)

Answer

Carbomer