Pharmacy Drug Delivery Systems 2

Question 1

Which parameter is MOST critical when designing a transdermal patch for a drug with high molecular weight?

Accepted Answer

Skin permeation enhancement

Answer

Tablet hardness

Answer

Capsule shell solubility

Answer

Viscosity of oral solution

Question 2

A drug formulated as a liposome is BEST described as:

Accepted Answer

A phospholipid bilayer vesicle encapsulating drug

Answer

A solid lipid nanoparticle

Answer

A microemulsion of oil and water

Answer

A polymer-drug conjugate

Question 3

Which route of administration completely bypasses first-pass metabolism?

Accepted Answer

Intravenous

Answer

Oral

Answer

Rectal (partial)

Answer

Sublingual

Question 4

An osmotic pump tablet (OROS) releases drug primarily by:

Accepted Answer

Osmotic pressure driving drug through a laser-drilled orifice

Answer

pH-triggered dissolution

Answer

Enzymatic degradation of the coating

Answer

Erosion of the wax matrix

Question 5

Which excipient class is commonly used in hot-melt extrusion to improve drug solubility?

Accepted Answer

Enteric polymers like HPMC-AS

Answer

Magnesium stearate

Answer

Microcrystalline cellulose

Answer

Talc

Question 6

Mucoadhesive drug delivery systems are designed primarily to:

Accepted Answer

Prolong contact time with mucosal membranes

Answer

Increase first-pass metabolism

Answer

Accelerate gastric emptying

Answer

Reduce drug particle size

Question 7

A nanoparticle drug carrier with a size of 10–200 nm is MOST likely to accumulate in tumor tissue via:

Accepted Answer

Enhanced permeability and retention (EPR) effect

Answer

Active receptor targeting only

Answer

Ion-pair transport

Answer

Carrier-mediated endocytosis exclusively