PEBC Pharmaceutical Calculations 2

Question 1

Using the alligation method, how many mL of 95% alcohol are needed to prepare 1000 mL of 70% alcohol (the other component being purified water)?

Accepted Answer

737 mL

Answer

700 mL

Answer

650 mL

Answer

750 mL

Question 2

Using the Cockcroft-Gault equation [CrCl = (140 − age) × weight / (72 × SCr)], what is the estimated creatinine clearance for a 65-year-old male, 70 kg, with a serum creatinine of 1.5 mg/dL?

Accepted Answer

49 mL/min

Answer

32 mL/min

Answer

54 mL/min

Answer

61 mL/min

Question 3

A pharmacist reconstitutes a 1 g vial of antibiotic powder by adding 9.3 mL of sterile water to yield a final volume of 10 mL. What is the powder volume?

Accepted Answer

0.7 mL

Answer

0.3 mL

Answer

0.5 mL

Answer

1.0 mL

Question 4

How many mL of a 10% stock solution are needed to prepare 500 mL of a 2% solution?

Accepted Answer

100 mL

Answer

50 mL

Answer

150 mL

Answer

200 mL

Question 5

A drug has a volume of distribution of 0.5 L/kg. A loading dose is required to achieve a target plasma concentration of 15 mg/L in a 70 kg patient. What is the loading dose?

Accepted Answer

525 mg

Answer

262.5 mg

Answer

1050 mg

Answer

750 mg

Question 6

A chemotherapy drug is dosed at 75 mg/m². A patient has a body surface area (BSA) of 1.8 m². What total dose should be administered?

Accepted Answer

135 mg

Answer

100 mg

Answer

125 mg

Answer

150 mg

Question 7

How many grams of zinc oxide are required to prepare 60 g of a 20% zinc oxide ointment?

Accepted Answer

12 g

Answer

6 g

Answer

16 g

Answer

20 g