PANRE Endocrinology 5

Question 1

A 60-year-old woman on bisphosphonate therapy for osteoporosis has a 'drug holiday' recommended after 5 years. Which bisphosphonate characteristic makes this most appropriate?

Accepted Answer

Prolonged skeletal retention and residual effect after discontinuation

Answer

Bisphosphonates have a prolonged half-life in bone (years), providing continued fracture protection after discontinuation, which supports a drug holiday to minimize risks like atypical femur fractures.

Question 2

Which HbA1c threshold is used to diagnose diabetes mellitus?

Accepted Answer

≥ 6.5%

Answer

An HbA1c ≥ 6.5% on two separate occasions (or once with confirmatory testing) meets the diagnostic criteria for diabetes mellitus per ADA guidelines.

Question 3

A patient with Hashimoto thyroiditis is euthyroid. What is the most appropriate management?

Accepted Answer

Monitor TSH periodically

Answer

Euthyroid Hashimoto thyroiditis requires no treatment; TSH should be monitored annually (or sooner if symptomatic) since hypothyroidism may develop over time.

Question 4

A 70-year-old man has a serum calcium of 11.4 mg/dL, PTH of 85 pg/mL (elevated), and eGFR of 72. He is asymptomatic. What is the best management?

Accepted Answer

Observation with monitoring of calcium, BMD, and renal function

Answer

Asymptomatic primary hyperparathyroidism with mild hypercalcemia and preserved renal function can be managed with watchful observation using periodic monitoring of calcium, BMD, and renal function per surgical guidelines.

Question 5

Which GLP-1 receptor agonist is approved for weight management in non-diabetic obese patients?

Accepted Answer

Semaglutide (2.4 mg subcutaneous weekly)

Answer

Semaglutide 2.4 mg weekly (Wegovy) is FDA-approved for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity.

PANRE Test Practice Test

PANRE Test Practice Test

PANRE Endocrinology 5