PANCE Hematology Flashcards
6 cards from real PANCE practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 PANCE Hematology flashcards as text
A patient has microcytic anemia, low serum ferritin, low serum iron, and elevated TIBC. What is the diagnosis?
Answer: Iron deficiency anemia
Low ferritin, low serum iron, and elevated TIBC are the hallmark lab findings of iron deficiency anemia.
A 70-year-old has macrocytic anemia, glossitis, and neurologic symptoms. Labs show elevated methylmalonic acid and homocysteine. What is the deficiency?
Answer: Vitamin B12
Elevated methylmalonic acid distinguishes B12 deficiency from folate deficiency, since only B12 is required in the MMA metabolic pathway.
A 28-year-old African American male develops hemolytic anemia after starting primaquine for malaria prophylaxis. What is the underlying enzyme deficiency?
Answer: G6PD deficiency
G6PD deficiency causes episodic hemolysis triggered by oxidative stressors like primaquine, dapsone, or fava beans.
A patient with sickle cell disease presents with acute bone pain, fever, and dactylitis. What is the most appropriate initial management?
Answer: IV fluids, oxygen, and analgesics
Acute vaso-occlusive crisis is managed with IV hydration, supplemental oxygen, and adequate analgesia.
A patient with CKD has normocytic anemia and a reticulocyte count of 0.5%. What is the most likely pathophysiologic cause?
Answer: Decreased erythropoietin production
CKD causes anemia primarily through decreased renal erythropoietin production, leading to inadequate red cell stimulation.
A patient has petechiae, mucosal bleeding, and a platelet count of 8,000. PT and aPTT are normal. What is the most likely diagnosis?
Answer: Immune thrombocytopenic purpura
ITP presents with isolated thrombocytopenia and normal coagulation studies, caused by autoantibodies against platelet glycoproteins.