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Dermatology Flashcards

7 cards from real PANCE practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. A 45-year-old woman presents with a salmon-colored, well-demarcated plaque with silvery scale on her elbows and knees. Which finding would most likely be seen on biopsy?

    Answer: Acanthosis with parakeratosis and Munro microabscesses

    Psoriasis classically shows acanthosis, parakeratosis, and Munro microabscesses (neutrophils in the stratum corneum).

  2. A 30-year-old man develops a targetoid lesion with a central blister after starting sulfonamide antibiotics. The lesion is localized to the palms. What is the most likely diagnosis?

    Answer: Erythema multiforme

    Erythema multiforme presents with classic targetoid (iris) lesions, often triggered by drugs or HSV, and is typically limited to acral surfaces.

  3. A 70-year-old farmer presents with a pearly, rolled-edge nodule with telangiectasias on his nose that occasionally bleeds. What is the first-line treatment?

    Answer: Mohs micrographic surgery

    Basal cell carcinoma on high-risk areas like the nose is best treated with Mohs surgery to achieve clear margins while sparing maximal tissue.

  4. A 25-year-old woman has an intensely pruritic, vesicular rash on the extensor surfaces of her elbows and knees. IgA deposits are found at the dermal-epidermal junction. What is the associated systemic condition?

    Answer: Celiac disease

    Dermatitis herpetiformis with IgA deposits is strongly associated with celiac disease (gluten-sensitive enteropathy).

  5. An 8-year-old child presents with honey-crusted erosions around the nares and mouth. Gram stain shows gram-positive cocci in clusters. What is the most appropriate treatment?

    Answer: Topical mupirocin or oral cephalexin

    Impetigo caused by Staphylococcus aureus is treated with topical mupirocin for localized disease or oral cephalexin for widespread infection.

  6. A 55-year-old man presents with dark, velvety thickening of the skin in the axillae and posterior neck. He also reports 20 lb weight loss over 2 months. What is the most important next step?

    Answer: Evaluate for underlying malignancy

    Acanthosis nigricans with rapid onset and weight loss suggests malignant acanthosis nigricans, most commonly associated with GI adenocarcinoma.

  7. A 40-year-old woman with butterfly-shaped erythema across her cheeks and nose presents after sun exposure. Her ANA is positive with anti-dsDNA antibodies. Which skin finding would be considered discoid lupus?

    Answer: Scarring plaques with follicular plugging and dyspigmentation

    Discoid lupus erythematosus features scarring plaques with follicular plugging, central atrophy, and dyspigmentation, potentially causing permanent hair loss.