PTCB Pharmacology #4 3

Question 1

Which drug suffix indicates a "-statin" belongs to the HMG-CoA reductase inhibitor class?

Accepted Answer

-vastatin

Answer

All HMG-CoA reductase inhibitors end in "-vastatin" (atorvastatin, rosuvastatin, simvastatin, pravastatin, lovastatin, fluvastatin, pitavastatin).

Question 2

Naloxone works by:

Accepted Answer

Competitively blocking opioid receptors

Answer

Naloxone (Narcan) is a competitive opioid receptor antagonist that rapidly displaces opioids from mu, kappa, and delta receptors, reversing respiratory depression, sedation, and analgesia within 2–5 minutes.

Question 3

Which drug is a selective serotonin-1A partial agonist used for generalized anxiety disorder?

Accepted Answer

Buspirone

Answer

Buspirone (Buspar) is a 5-HT1A partial agonist used for GAD. Unlike benzodiazepines, it has no abuse potential, no sedation, and requires 2–4 weeks for full anxiolytic effect.

Question 4

Digoxin toxicity can be precipitated by which electrolyte imbalance?

Accepted Answer

Hypokalemia

Answer

Hypokalemia (low potassium) increases digoxin toxicity because potassium and digoxin compete for the same binding site on Na+/K+ ATPase. Diuretic-induced hypokalemia is a common precipitant of toxicity.

Question 5

Which of the following describes "tolerance" in pharmacology?

Accepted Answer

The need for increasing doses to achieve the same effect with repeated use

Answer

Tolerance is the reduced pharmacological response to a drug after repeated administration, requiring higher doses to achieve the original effect. It is common with opioids, benzodiazepines, and nitrates.

Pharmacy Practice Test

Pharmacy Practice Test

PTCB Pharmacology #4 3