Pharmacy Pharmacology 2

Question 1

Which class of drugs works by blocking H2 receptors to reduce gastric acid secretion?

Accepted Answer

H2 blockers

Answer

H2 blockers (e.g., ranitidine, famotidine) competitively block histamine H2 receptors on parietal cells, reducing acid production.

Question 2

Metformin's primary mechanism of action for treating type 2 diabetes is to:

Accepted Answer

Decrease hepatic glucose production

Answer

Metformin primarily decreases hepatic gluconeogenesis and improves insulin sensitivity; it does not stimulate insulin secretion.

Question 3

Which term describes the study of how the body affects a drug (absorption, distribution, metabolism, excretion)?

Accepted Answer

Pharmacokinetics

Answer

Pharmacokinetics (PK) describes how the body processes a drug — ADME: Absorption, Distribution, Metabolism, Excretion.

Question 4

A drug with a narrow therapeutic index requires close monitoring because:

Accepted Answer

The difference between effective and toxic doses is small

Answer

Narrow therapeutic index drugs (e.g., warfarin, digoxin, lithium) have minimal margin between therapeutic and toxic plasma levels.

Question 5

Beta-1 selective adrenergic blockers are preferred in asthmatic patients because they:

Accepted Answer

Avoid bronchoconstriction caused by beta-2 blockade

Answer

Cardioselective (beta-1 selective) blockers like metoprolol minimize bronchospasm risk by avoiding beta-2 receptor blockade in the lungs.

Pharmacy Practice Test