MFDS Pharmacology

Question 1

Articaine differs from other amide local anaesthetics in that it contains:

Accepted Answer

A thiophene ring

Answer

Articaine uniquely contains a thiophene ring instead of a benzene ring, which increases its lipid solubility and ability to diffuse through bone.

Question 2

The maximum recommended dose of lidocaine with adrenaline for a healthy adult is approximately:

Accepted Answer

7 mg/kg (max 500 mg)

Answer

Lidocaine with adrenaline (epinephrine) has a maximum recommended dose of 7 mg/kg up to 500 mg in healthy adults, higher than plain lidocaine due to vasoconstriction.

Question 3

Which antibiotic is first-line for odontogenic infections in penicillin-allergic patients?

Accepted Answer

Clindamycin

Answer

Clindamycin is an appropriate first-line alternative for odontogenic infections in penicillin-allergic patients due to its excellent activity against streptococci and anaerobes.

Question 4

NSAIDs exert their analgesic effect primarily by inhibiting which enzyme?

Accepted Answer

Cyclooxygenase (COX)

Answer

NSAIDs inhibit cyclooxygenase (COX-1 and COX-2) enzymes, thereby blocking prostaglandin synthesis and reducing pain, inflammation and fever.

Question 5

Fluconazole is the drug of choice for treating which oral fungal infection?

Accepted Answer

Oropharyngeal candidiasis

Answer

Fluconazole, a triazole antifungal, is highly effective and well tolerated for oropharyngeal and oesophageal candidiasis, particularly in immunocompromised patients.

MFDS Part 1 Practice Test

MFDS Part 1 Practice Test

MFDS Pharmacology