MFDS Oral Medicine & Pathology 3

Question 1

The acanthosis, elongation of rete ridges and parakeratosis seen on biopsy are most consistent with:

Accepted Answer

Psoriasiform mucositis

Answer

Psoriasiform mucositis shows elongated rete ridges, acanthosis and parakeratosis similar to psoriasis of the skin, and may be associated with geographic tongue or fissured tongue.

Question 2

Which classification is used to grade epithelial dysplasia in oral precancerous lesions?

Accepted Answer

WHO 2005 grading

Answer

The WHO 2005 system grades oral epithelial dysplasia as mild, moderate or severe (or uses a binary low-grade/high-grade system) based on architectural and cytological criteria.

Question 3

Verrucous carcinoma differs from conventional SCC in that it:

Accepted Answer

Has a pushing border and low-grade histology

Answer

Verrucous carcinoma is a low-grade variant of SCC with a pushing (non-infiltrative) border, minimal cytological atypia and an excellent prognosis with complete excision.

Question 4

Which investigation is most appropriate to confirm the diagnosis of pemphigus vulgaris?

Accepted Answer

Direct immunofluorescence of perilesional mucosa

Answer

Direct immunofluorescence of perilesional mucosa demonstrates intercellular IgG and C3 deposition in a 'chicken wire' or 'fish net' pattern, confirming pemphigus vulgaris.

Question 5

Mikulicz cells, which are large macrophages containing the causative organism, are found in:

Accepted Answer

Rhinoscleroma

Answer

Rhinoscleroma (caused by Klebsiella rhinoscleromatis) is characterised by large vacuolated macrophages called Mikulicz cells containing the organisms.

MFDS Part 1 Practice Test

MFDS Part 1 Practice Test

MFDS Oral Medicine & Pathology 3