A nurse reads that a new antihypertensive reduced systolic BP by 12 mmHg on average in a trial of 800 patients. She wants to apply this finding to her 70-year-old patient. Which analytical step is MOST critical before doing so?
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A
Check whether the trial population matches her patient's age, comorbidities, and demographics
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B
Accept the finding because a large sample size guarantees applicability
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C
Apply the drug immediately since 12 mmHg is a clinically significant reduction
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D
Dismiss the finding because trials never reflect real-world patients