CRNA CRNA Pharmacology and Anesthesia Agents

Question 1

Which inhalational anesthetic agent has the lowest blood-gas partition coefficient, resulting in the fastest induction and emergence?

Accepted Answer

Desflurane

Answer

Desflurane has the lowest blood-gas partition coefficient (0.45), allowing the fastest induction and emergence among commonly used inhalational agents.

Question 2

A patient receives succinylcholine and develops masseter muscle rigidity followed by rapidly rising temperature. What is the most likely diagnosis?

Accepted Answer

Malignant hyperthermia

Answer

Masseter muscle rigidity after succinylcholine is a hallmark early sign of malignant hyperthermia, a life-threatening hypermetabolic crisis triggered by volatile agents and succinylcholine.

Question 3

Which opioid is most appropriate for a patient with renal failure requiring intraoperative analgesia due to its lack of active metabolites?

Accepted Answer

Remifentanil

Answer

Remifentanil is metabolized by nonspecific plasma esterases and has no active metabolites, making it safe in renal failure.

Question 4

What is the mechanism of action of neostigmine used for reversal of neuromuscular blockade?

Accepted Answer

Acetylcholinesterase inhibition

Answer

Neostigmine inhibits acetylcholinesterase, increasing acetylcholine concentration at the neuromuscular junction to displace and overcome non-depolarizing blockers.

Question 5

Which benzodiazepine is preferred for IV sedation due to its water solubility and lack of pain on injection?

Accepted Answer

Midazolam

Answer

Midazolam is water-soluble at low pH, becoming lipophilic at physiologic pH, making it painless on injection and suitable for IV sedation.

CRNA - Certified Registered Nurse Anesthetist Practice Test

CRNA - Certified Registered Nurse Anesthetist Practice Test

CRNA CRNA Pharmacology and Anesthesia Agents