ASCP Immunohematology (Blood Banking)

Question 1

A patient with blood type A positive has which antigens on their red blood cells?

Accepted Answer

A antigen and Rh (D) antigen

Answer

Blood type A positive means the RBCs carry the A antigen (ABO) and the D antigen (Rh system).

Question 2

What antibodies does a type O negative individual have in their serum?

Accepted Answer

Anti-A, anti-B, and anti-D

Answer

Type O individuals have both anti-A and anti-B; Rh-negative individuals may have or form anti-D, so O negative serum contains all three.

Question 3

The direct antiglobulin test (DAT) detects:

Accepted Answer

Antibody or complement bound to patient's RBCs in vivo

Answer

The DAT uses antihuman globulin to detect IgG or complement already coating the patient's red blood cells.

Question 4

Which blood component contains the highest concentration of clotting factors including fibrinogen?

Accepted Answer

Fresh frozen plasma (FFP)

Answer

Fresh frozen plasma contains all coagulation factors at near-normal concentrations and is used for multiple factor deficiencies.

Question 5

Hemolytic disease of the fetus and newborn (HDFN) most commonly involves which antibody?

Accepted Answer

Anti-D (IgG)

Answer

Anti-D is IgG and crosses the placenta; Rh-negative mothers sensitized by Rh-positive fetal cells can develop anti-D causing HDFN.

ASCP Practice Test