ASCP Hematology

Question 1

Which cell type is characterized by a bilobed nucleus connected by a thin strand and is elevated in allergic reactions?

Accepted Answer

Eosinophil

Answer

Eosinophils have bilobed nuclei and are elevated in allergic reactions and parasitic infections.

Question 2

A patient with iron deficiency anemia would most likely show which RBC morphology?

Accepted Answer

Microcytosis and hypochromia

Answer

Iron deficiency anemia causes microcytic, hypochromic red blood cells due to impaired hemoglobin synthesis.

Question 3

What is the normal reference range for platelet count in adults?

Accepted Answer

150,000–400,000/µL

Answer

The normal adult platelet count is 150,000–400,000 per microliter.

Question 4

Which hemoglobin type predominates in adults and consists of two alpha and two beta chains?

Accepted Answer

HbA1

Answer

HbA1 (α2β2) makes up approximately 95–98% of total hemoglobin in normal adults.

Question 5

A peripheral blood smear shows hypersegmented neutrophils. This finding is most consistent with:

Accepted Answer

Megaloblastic anemia

Answer

Hypersegmented neutrophils (5+ lobes) are a hallmark of megaloblastic anemia caused by B12 or folate deficiency.

ASCP Practice Test