Neonatal Nurse Practitioner Exam Pharmacology and Medications 3

Question 1

Which reversal agent is used for opioid-induced respiratory depression in a neonate?

Accepted Answer

Naloxone

Answer

Flumazenil

Answer

Protamine sulfate

Answer

Sugammadex

Question 2

A neonate with congenital hypothyroidism requires levothyroxine therapy. What is the main reason for urgent treatment?

Accepted Answer

Prevent irreversible neurodevelopmental impairment

Answer

Prevent cardiac arrhythmias

Answer

Prevent growth hormone deficiency

Answer

Treat neonatal jaundice

Question 3

Which antifungal is most commonly used for invasive candidiasis in premature neonates?

Accepted Answer

Fluconazole IV

Answer

Caspofungin

Answer

Itraconazole

Answer

Nystatin oral

Question 4

Dexamethasone given postnatally for BPD carries a significant risk of:

Accepted Answer

Neurodevelopmental impairment and GI perforation

Answer

Hypoglycemia only

Answer

Anemia

Answer

Pulmonary hemorrhage

Question 5

What is the mechanism of action of phenytoin in treating neonatal seizures?

Accepted Answer

Blocks voltage-gated sodium channels to stabilize neuronal membranes

Answer

Enhances GABA-A receptor activity

Answer

Inhibits NMDA receptor activation

Answer

Increases chloride conductance

Question 6

A neonate with early-onset GBS sepsis. After 48 hours of ampicillin and gentamicin with confirmed GBS sensitivity, gentamicin should be:

Accepted Answer

Discontinued and ampicillin continued alone as narrower-spectrum therapy

Answer

Continued for the full course

Answer

Switched to vancomycin

Answer

Replaced with cefazolin