NCCPA Pharmacology 4

Question 1

A patient taking clozapine develops a fever, sore throat, and absolute neutrophil count of 400/µL. What is the appropriate action?

Accepted Answer

Discontinue clozapine immediately and monitor CBC

Answer

Reduce clozapine dose by 50%

Answer

Add filgrastim and continue clozapine

Answer

Switch to olanzapine and continue monitoring

Question 2

Which medication used for alcohol use disorder causes an aversive reaction when alcohol is consumed by blocking aldehyde dehydrogenase?

Accepted Answer

Disulfiram

Answer

Naltrexone

Answer

Acamprosate

Answer

Topiramate

Question 3

Which antiarrhythmic drug prolongs QT interval the most and carries the highest risk of torsades de pointes?

Accepted Answer

Sotalol

Answer

Lidocaine

Answer

Flecainide

Answer

Adenosine

Question 4

A patient with Parkinson's disease on levodopa/carbidopa develops visual hallucinations. Which medication is preferred to treat psychosis while preserving motor function?

Accepted Answer

Quetiapine

Answer

Haloperidol

Answer

Olanzapine

Answer

Risperidone

Question 5

Which drug is the antidote for acetaminophen overdose and works by replenishing glutathione stores?

Accepted Answer

N-acetylcysteine

Answer

Flumazenil

Answer

Naloxone

Answer

Physostigmine

Question 6

A patient on rifampin for tuberculosis has decreased efficacy of her oral contraceptive. What is the mechanism?

Accepted Answer

Rifampin induces CYP3A4, accelerating contraceptive metabolism

Answer

Rifampin inhibits estrogen synthesis

Answer

Rifampin blocks progesterone receptors

Answer

Rifampin reduces GI absorption of hormones

Question 7

Which diuretic is most effective for acute pulmonary edema and works by inhibiting the Na-K-2Cl cotransporter in the loop of Henle?

Accepted Answer

Furosemide

Answer

Hydrochlorothiazide

Answer

Acetazolamide

Answer

Spironolactone