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Pharmacology and Drug Mechanisms Flashcards

7 cards from real NAPLEX QBANK practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Which mechanism describes digoxin's positive inotropic effect?

    Answer: Inhibition of Na+/K+ ATPase increasing intracellular calcium

    Digoxin inhibits Na+/K+ ATPase, indirectly raising intracellular calcium for stronger contraction.

  2. Which anticoagulant directly inhibits factor Xa?

    Answer: Rivaroxaban

    Rivaroxaban is a direct oral factor Xa inhibitor.

  3. Beta-blockers reduce heart rate primarily by antagonizing which receptor?

    Answer: Beta-1 adrenergic receptors

    Blocking cardiac beta-1 receptors decreases heart rate and contractility.

  4. Which drug interaction increases risk of serotonin syndrome?

    Answer: SSRI plus MAO inhibitor

    Combining serotonergic agents like SSRIs with MAOIs can cause serotonin syndrome.

  5. ACE inhibitors cause cough primarily due to accumulation of:

    Answer: Bradykinin

    ACE also degrades bradykinin; its buildup triggers the characteristic dry cough.

  6. Which agent reverses dabigatran anticoagulation?

    Answer: Idarucizumab

    Idarucizumab is a monoclonal antibody fragment specific for dabigatran reversal.

  7. Which mechanism best describes the action of montelukast?

    Answer: Leukotriene receptor antagonism

    Montelukast blocks the CysLT1 leukotriene receptor, reducing bronchoconstriction and inflammation.