NAPLEX QBANK Sterile and Non-Sterile Compounding Questions and Answers

Question 1

A pharmacist needs to compound an ointment containing 100 mg of a potent corticosteroid powder using 19.9 g of a petrolatum base.
To ensure the active ingredient is uniformly distributed, which of the following compounding techniques is most appropriate?

Accepted Answer

Geometric dilution

Answer

Spatulation on an ointment slab without any specific order

Answer

Tumbling in a motorized mixer for 10 minutes

Answer

Levigation with a volatile solvent

Question 2

According to USP Chapter <797>, which of the following represents the correct sequence for donning personal protective equipment (PPE) before entering the buffer area for sterile compounding?

Accepted Answer

Don shoe covers and hair cover, wash hands, don gown, apply alcohol-based hand scrub, don sterile gloves.

Answer

Don gown, wash hands, don sterile gloves, don shoe covers.

Answer

Wash hands, don shoe covers, don gown, don sterile gloves in buffer area.

Answer

Don sterile gloves, don gown, wash hands, don hair cover.

Question 3

A batch of parenteral nutrition (PN) solutions is prepared in an ISO 5 primary engineering control located within an ISO 7 buffer room. The compounding involves multiple additions and manipulations. According to the revised USP <797> guidelines, what is the maximum beyond-use date (BUD) for this Compounded Sterile Product (CSP) if it is stored in a refrigerator?

Accepted Answer

9 days

Answer

48 hours

Answer

30 hours

Answer

14 days

Question 4

A pharmacist is preparing a powdered formulation and needs to reduce the particle size of a coarse, crystalline substance to create a fine, uniform powder. Which non-sterile compounding technique best describes this process?

Accepted Answer

Trituration

Answer

Levigation

Answer

Spatulation

Answer

Eutectic mixing

Question 5

Which of the following correctly describes the air pressure relationship required by USP <797> for a non-hazardous sterile compounding cleanroom suite?

Accepted Answer

The buffer area must be at a positive pressure to the anteroom, and the anteroom must be at a positive pressure to the general pharmacy area.

Answer

The buffer area and anteroom must be at a negative pressure relative to the general pharmacy area.

Answer

The anteroom must be at a higher positive pressure than the buffer area to create an air lock.

Answer

All compounding areas, including the buffer and anteroom, should have equal air pressure to the surrounding pharmacy.

Question 6

A technician needs to accurately measure 8 mL of glycerin, a viscous liquid, for a non-sterile compound. Which piece of equipment would provide the most accurate measurement?

Accepted Answer

A 10 mL oral syringe

Answer

A 10 mL beaker

Answer

A 25 mL graduated cylinder

Answer

A 50 mL conical graduate

A pharmacist needs to compound an ointment containing 100 mg of a potent corticosteroid powder using 19.9 g of a petrolatum base.To ensure the active ingredient is uniformly distributed, which of the following compounding techniques is most appropriate?

A pharmacist needs to compound an ointment containing 100 mg of a potent corticosteroid powder using 19.9 g of a petrolatum base.
To ensure the active ingredient is uniformly distributed, which of the following compounding techniques is most appropriate?