MSN Pharmacology for Advanced Practice

Question 1

Which receptor mechanism do beta-1 adrenergic antagonists (beta-blockers) use to reduce heart rate?

Accepted Answer

Competitively block catecholamine binding at beta-1 adrenergic receptors in the SA node

Answer

Block muscarinic receptors in the SA node

Answer

Activate potassium channels to hyperpolarize cardiac cells

Answer

Inhibit phosphodiesterase to reduce cyclic AMP

Question 2

A patient prescribed warfarin reports adding cranberry juice to their daily diet. What pharmacokinetic concern should the NP have?

Accepted Answer

Cranberry juice inhibits CYP2C9, potentially increasing warfarin levels and bleeding risk

Answer

Cranberry juice induces CYP2C9, reducing warfarin levels

Answer

Cranberry juice directly binds warfarin, reducing absorption

Answer

No significant interaction exists between cranberry and warfarin

Question 3

Which class of antihypertensive is first-line for a patient with hypertension and a new diagnosis of chronic kidney disease with proteinuria?

Accepted Answer

ACE inhibitors or ARBs

Answer

Thiazide diuretics

Answer

Dihydropyridine calcium channel blockers

Answer

Beta-blockers

Question 4

The narrow therapeutic index of digoxin means that which monitoring parameter is most critical?

Accepted Answer

Serum digoxin level, renal function, and serum potassium

Answer

Liver function tests

Answer

Complete blood count

Answer

Thyroid function tests

Question 5

Which pharmacodynamic property describes a drug that binds a receptor and produces a maximal response?

Accepted Answer

Full agonist

Answer

Partial agonist

Answer

Competitive antagonist

Answer

Inverse agonist

Question 6

Proton pump inhibitors (PPIs) are prodrugs that require which condition to become active?

Accepted Answer

Acidic pH in the parietal cell canaliculus to convert to the active sulfenamide

Answer

Alkaline pH in the small intestine

Answer

First-pass metabolism in the liver

Answer

Enzymatic conversion by colonic bacteria