MSN Pharmacology for Advanced Practice 3

Question 1

Which class of drugs is the recommended first-line pharmacotherapy for smoking cessation in adults?

Accepted Answer

Varenicline (Chantix) — highest abstinence rates

Answer

Nicotine replacement therapy (NRT) alone

Answer

Bupropion SR alone

Answer

Nortriptyline — second-line only

Question 2

Serotonin syndrome is most likely to occur when which drug combination is used?

Accepted Answer

SSRI plus MAO inhibitor

Answer

SSRI plus beta-blocker

Answer

SSRI plus diuretic

Answer

Tricyclic antidepressant plus calcium channel blocker

Question 3

Which pharmacokinetic parameter determines the dosing interval for a drug?

Accepted Answer

Half-life

Answer

Volume of distribution

Answer

Bioavailability

Answer

Protein binding percentage

Question 4

Statins reduce cardiovascular risk primarily by which mechanism beyond LDL lowering?

Accepted Answer

Pleiotropic effects including anti-inflammatory activity and plaque stabilization

Answer

Direct vasodilation of coronary arteries

Answer

Increasing HDL cholesterol synthesis

Answer

Inhibiting platelet aggregation via COX-1 blockade

Question 5

A patient develops a dry, persistent cough after starting lisinopril. What is the pharmacological explanation?

Accepted Answer

ACE inhibition prevents bradykinin degradation; accumulated bradykinin irritates the airway

Answer

ACE inhibitors increase prostaglandin synthesis causing airway inflammation

Answer

The drug directly stimulates the cough center in the medulla

Answer

Lisinopril causes pulmonary edema leading to cough

Question 6

Which antidiabetic drug class works by inhibiting renal glucose reabsorption via SGLT-2 transporters?

Accepted Answer

SGLT-2 inhibitors (gliflozins)

Answer

DPP-4 inhibitors (gliptins)

Answer

GLP-1 receptor agonists

Answer

Sulfonylureas