MRCP Part 1 Haematology, Infectious Disease & Dermatology

Question 1

A 70-year-old man has a haemoglobin of 70 g/L, MCV 120 fL, and hypersegmented neutrophils on blood film. Vitamin B12 is low. What is the most likely cause of B12 deficiency?

Accepted Answer

Pernicious anaemia

Answer

Dietary deficiency in a vegan

Answer

Terminal ileal resection

Answer

Metformin therapy

Question 2

A patient presents with petechiae, gum bleeding, and a platelet count of 8 × 10⁹/L. Blood film shows no clumping. What is the diagnosis?

Accepted Answer

Immune thrombocytopenia (ITP)

Answer

Thrombotic thrombocytopenic purpura

Answer

Disseminated intravascular coagulation

Answer

Heparin-induced thrombocytopenia

Question 3

Which marker is used to guide treatment decisions and monitor prognosis in non-Hodgkin's lymphoma?

Accepted Answer

Lactate dehydrogenase (LDH)

Answer

Beta-2 microglobulin

Answer

Serum ferritin

Answer

Alkaline phosphatase

Question 4

A patient returning from sub-Saharan Africa presents with fever, rigors, and splenomegaly. Thick and thin blood films show ring forms within red blood cells. What is the treatment for falciparum malaria without complications?

Accepted Answer

Artemether-lumefantrine (Riamet)

Answer

Chloroquine

Answer

Quinine plus doxycycline

Answer

Mefloquine

Question 5

In disseminated intravascular coagulation (DIC), which coagulation profile would you expect?

Accepted Answer

Elevated PT, elevated APTT, reduced fibrinogen, reduced platelets

Answer

Elevated PT, elevated APTT, elevated fibrinogen, elevated platelets

Answer

Normal PT, elevated APTT, elevated fibrinogen, reduced platelets

Answer

Reduced PT, reduced APTT, elevated fibrinogen, elevated platelets

Question 6

A patient with a chronic leg ulcer has a painful, violaceous, undermined border wound. Skin biopsy shows neutrophilic infiltrate without infection. What is the diagnosis?

Accepted Answer

Pyoderma gangrenosum

Answer

Squamous cell carcinoma

Answer

Vasculitis

Answer

Lipodermatosclerosis