MRCP Part 1 Clinical Sciences

Question 1

A 45-year-old man presents with muscle weakness and hypokalaemia. His arterial blood gas shows metabolic alkalosis. Which hormone, if produced in excess, is most likely responsible?

Accepted Answer

Aldosterone

Answer

Cortisol

Answer

Adrenaline

Answer

Thyroxine

Question 2

Which immunoglobulin class is found in highest concentration in normal human serum?

Accepted Answer

IgG

Answer

IgA

Answer

IgM

Answer

IgE

Question 3

A patient with chronic kidney disease has a corrected calcium of 1.9 mmol/L and phosphate of 2.1 mmol/L. Which is the most likely underlying mechanism?

Accepted Answer

Reduced renal 1-alpha-hydroxylase activity

Answer

Increased PTH secretion

Answer

Vitamin D toxicity

Answer

Primary hyperparathyroidism

Question 4

Which type of hypersensitivity reaction is responsible for Goodpasture's syndrome?

Accepted Answer

Type II (cytotoxic)

Answer

Type I (immediate)

Answer

Type III (immune complex)

Answer

Type IV (delayed)

Question 5

A 30-year-old woman has a serum sodium of 118 mmol/L, serum osmolality of 260 mOsm/kg, and urine osmolality of 550 mOsm/kg. She is clinically euvolaemic. What is the most likely diagnosis?

Accepted Answer

Syndrome of inappropriate ADH secretion (SIADH)

Answer

Addison's disease

Answer

Psychogenic polydipsia

Answer

Nephrotic syndrome

Question 6

Which enzyme deficiency is responsible for acute intermittent porphyria?

Accepted Answer

Porphobilinogen deaminase

Answer

ALA synthase

Answer

Ferrochelatase

Answer

Uroporphyrinogen decarboxylase

A 45-year-old man presents with muscle weakness and hypokalaemia.His arterial blood gas shows metabolic alkalosis.Which hormone, if produced in excess, is most likely responsible?

A 45-year-old man presents with muscle weakness and hypokalaemia.
His arterial blood gas shows metabolic alkalosis.
Which hormone, if produced in excess, is most likely responsible?