MOH Pharmacology & Drug Regulations 2

Question 1

Which class of antibiotics is contraindicated in children under 8 years of age due to dental staining?

Accepted Answer

Tetracyclines

Answer

Tetracyclines chelate calcium and deposit in developing teeth and bones, causing permanent yellow-brown staining when given to children under 8 years.

Question 2

A patient taking ACE inhibitors develops a dry persistent cough. The MOST appropriate action is:

Accepted Answer

Switch to an angiotensin receptor blocker (ARB)

Answer

ACE inhibitor-induced cough is caused by bradykinin accumulation and is a class effect; switching to an ARB avoids this side effect while maintaining renin-angiotensin system blockade.

Question 3

Heparin overdose is treated with:

Accepted Answer

Protamine sulfate

Answer

Protamine sulfate binds and neutralizes heparin through ionic interaction, rapidly reversing anticoagulation in heparin overdose.

Question 4

Which diuretic class is the first-line treatment for nephrogenic diabetes insipidus?

Accepted Answer

Thiazide diuretics

Answer

Thiazide diuretics paradoxically reduce urine output in nephrogenic DI by inducing mild volume depletion, increasing proximal tubular water reabsorption.

Question 5

What is the maximum safe daily dose of acetaminophen (paracetamol) in a healthy adult?

Accepted Answer

4 grams

Answer

The maximum recommended dose of acetaminophen in healthy adults is 4 grams per day; doses exceeding this risk hepatotoxicity due to accumulation of the toxic NAPQI metabolite.

MOH UAE Practice Test

MOH UAE Practice Test

MOH Pharmacology & Drug Regulations 2