MLS Blood Banking & Transfusion Medicine 2

Question 1

Which transfusion reaction presents with fever, chills, and rigors within 1–6 hours post-transfusion without evidence of hemolysis?

Accepted Answer

Febrile non-hemolytic transfusion reaction (FNHTR)

Answer

Acute hemolytic transfusion reaction

Answer

Allergic/urticarial reaction

Answer

Transfusion-associated circulatory overload (TACO)

Question 2

Transfusion-related acute lung injury (TRALI) is primarily caused by:

Accepted Answer

Donor antibodies activating recipient neutrophils in the lung vasculature

Answer

ABO incompatibility between donor and recipient

Answer

Bacterial contamination of the blood product

Answer

Iron overload from chronic transfusion therapy

Question 3

An antibody identification panel in the blood bank is primarily used to:

Accepted Answer

Identify the specificity of unexpected antibodies in patient serum

Answer

Confirm a patient's ABO and Rh blood type

Answer

Screen donor blood for infectious disease markers

Answer

Assess platelet function before transfusion

Question 4

The Kleihauer-Betke acid elution test is used to:

Accepted Answer

Quantify the volume of fetal red cells in maternal circulation

Answer

Identify the Rh type of a newborn

Answer

Detect irregular antibodies in prenatal patients

Answer

Confirm ABO blood group in neonates

Question 5

An acute hemolytic transfusion reaction (AHTR) is most commonly caused by:

Accepted Answer

ABO incompatibility due to clerical or identification error

Answer

Bacterial contamination of the blood unit

Answer

Allergic response to donor plasma proteins

Answer

Leukocyte cytokines in stored blood products

Question 6

Warm autoimmune hemolytic anemia (WAIHA) is most commonly associated with which type of autoantibody?

Accepted Answer

IgG pan-reactive antibody active at 37°C

Answer

IgM cold-reactive agglutinin

Answer

IgA anti-D alloantibody

Answer

IgM anti-I antibody

Question 7

Enzyme treatment of reagent red cells (e.g., with papain or ficin) enhances detection of antibodies in which blood group systems?

Accepted Answer

Rh and Kidd systems

Answer

MNS and Duffy systems

Answer

ABO and Lewis systems

Answer

Kell and Lutheran systems