Oral Medicine & Pathology Flashcards

The acanthosis, elongation of rete ridges and parakeratosis seen on biopsy are most consistent with:

Answer: Psoriasiform mucositis

Psoriasiform mucositis shows elongated rete ridges, acanthosis and parakeratosis similar to psoriasis of the skin, and may be associated with geographic tongue or fissured tongue.

Which classification is used to grade epithelial dysplasia in oral precancerous lesions?

Answer: WHO 2005 grading

The WHO 2005 system grades oral epithelial dysplasia as mild, moderate or severe (or uses a binary low-grade/high-grade system) based on architectural and cytological criteria.

Verrucous carcinoma differs from conventional SCC in that it:

Answer: Has a pushing border and low-grade histology

Verrucous carcinoma is a low-grade variant of SCC with a pushing (non-infiltrative) border, minimal cytological atypia and an excellent prognosis with complete excision.

Which investigation is most appropriate to confirm the diagnosis of pemphigus vulgaris?

Answer: Direct immunofluorescence of perilesional mucosa

Direct immunofluorescence of perilesional mucosa demonstrates intercellular IgG and C3 deposition in a 'chicken wire' or 'fish net' pattern, confirming pemphigus vulgaris.

Mikulicz cells, which are large macrophages containing the causative organism, are found in:

Answer: Rhinoscleroma

Rhinoscleroma (caused by Klebsiella rhinoscleromatis) is characterised by large vacuolated macrophages called Mikulicz cells containing the organisms.

Florid cemento-osseous dysplasia most commonly affects which demographic group?

Answer: Middle-aged black women

Florid cemento-osseous dysplasia has a strong predilection for middle-aged black women and is typically an incidental radiographic finding requiring no treatment.