MFDS Oral Medicine & Pathology 2 — Questions and Answers
Question 1: Which condition is characterised by multiple dentigerous cysts, odontogenic keratocysts and calcifying jaw cysts as part of a syndrome?
- Gardner syndrome
- Gorlin-Goltz syndrome (Correct answer)
- Paget's disease
- Cherubism
Correct answer: Gorlin-Goltz syndrome
Gorlin-Goltz syndrome (naevoid basal cell carcinoma syndrome) is caused by PTCH1 mutation and includes multiple OKCs, basal cell carcinomas and skeletal anomalies.
Question 2: Ranula is a mucocele arising from which gland?
- Parotid gland
- Sublingual gland (Correct answer)
- Submandibular gland
- Minor salivary glands
Correct answer: Sublingual gland
A ranula is a pseudocyst (extravasation mucocele) arising from the sublingual gland, producing a bluish, fluctuant swelling in the floor of the mouth.
Question 3: Cotton wool appearance on radiographs is characteristic of which condition?
- Osteosarcoma
- Paget's disease of bone (Correct answer)
- Fibrous dysplasia
- Multiple myeloma
Correct answer: Paget's disease of bone
Paget's disease in the remodelling (mixed) phase produces a characteristic 'cotton wool' or 'ground glass' radiographic appearance due to disorganised woven bone formation.
Question 4: Which marker is elevated in Sjögren's syndrome and is used diagnostically?
- Anti-dsDNA
- Anti-Ro (SSA) and Anti-La (SSB) (Correct answer)
- ANA only
- ANCA
Correct answer: Anti-Ro (SSA) and Anti-La (SSB)
Anti-Ro (SSA) and Anti-La (SSB) antibodies are characteristic of Sjögren's syndrome and form part of the international diagnostic criteria for the condition.
Question 5: Koplik's spots in the oral mucosa are a prodromal feature of:
- Varicella
- Measles (Correct answer)
- Hand foot and mouth disease
- Scarlet fever
Correct answer: Measles
Koplik's spots (bluish-white spots on a red background on the buccal mucosa opposite the molars) appear 1–2 days before the skin rash of measles.
Question 6: Which form of aphthous ulceration leaves scarring on healing?
- Minor aphthous ulcers
- Major aphthous ulcers (Correct answer)
- Herpetiform ulcers
- All aphthous ulcers
Correct answer: Major aphthous ulcers
Major aphthous ulcers (Sutton's disease) are large, deep and slow-healing ulcers that frequently leave scarring, unlike the minor form which heals without scar.
MFDS Oral Medicine & Pathology 2
Which condition is characterised by multiple dentigerous cysts, odontogenic keratocysts and calcifying jaw cysts as part of a syndrome?