MFDS Human Disease 2

Question 1

Which cardiac condition most significantly increases the risk of prolonged QT syndrome with erythromycin?

Accepted Answer

Pre-existing QT prolongation or concurrent QT-prolonging drugs

Answer

Mitral valve prolapse

Answer

Atrial fibrillation

Answer

Left bundle branch block

Question 2

Behçet's disease is characterised by the triad of:

Accepted Answer

Oral ulcers, genital ulcers and uveitis

Answer

Oral ulcers, arthritis and psoriasis

Answer

Xerostomia, arthritis and keratoconjunctivitis

Answer

Oral ulcers, skin lesions and hepatitis

Question 3

Which liver disease most significantly impairs drug metabolism in dental practice?

Accepted Answer

Severe cirrhosis

Answer

Hepatitis A (acute)

Answer

Non-alcoholic fatty liver disease

Answer

Primary biliary cholangitis (early stage)

Question 4

A patient with chronic renal failure presents for extraction. The main concern regarding drug prescribing is:

Accepted Answer

Accumulation of renally excreted drugs and metabolites

Answer

Increased hepatic clearance of drugs

Answer

Resistance to local anaesthetics

Answer

Reduced need for antibiotics

Question 5

Which immune deficiency syndrome most significantly predisposes to invasive oral candidiasis?

Accepted Answer

HIV/AIDS (CD4 <200)

Answer

IgA deficiency

Answer

Common variable immunodeficiency

Answer

Chronic granulomatous disease

Question 6

Which feature distinguishes Crohn's disease from ulcerative colitis in oral manifestations?

Accepted Answer

Cobblestone buccal mucosa and lip swelling occur in Crohn's

Answer

Aphthous ulcers are exclusive to UC

Answer

Pyostomatitis vegetans is only in Crohn's

Answer

Geographic tongue is specific to UC