Mesothelioma Therapy Immunotherapy and Targeted Therapy 2

Question 1

Mesothelin is a target in mesothelioma because it is:

Accepted Answer

Overexpressed on mesothelioma cell surfaces

Answer

Mesothelin is highly overexpressed on the surface of mesothelioma cells, making it an attractive target for antibody-based therapies.

Question 2

Amatuximab is an experimental targeted therapy for mesothelioma that targets which protein?

Accepted Answer

Mesothelin

Answer

Amatuximab is a chimeric anti-mesothelin monoclonal antibody being investigated as a targeted therapy for mesothelin-expressing mesothelioma.

Question 3

CAR-T cell therapy in mesothelioma research primarily targets which antigen?

Accepted Answer

Mesothelin

Answer

CAR-T cell therapies for mesothelioma are primarily engineered to target mesothelin, which is abundantly expressed on mesothelioma cells.

Question 4

Pembrolizumab targets which checkpoint molecule?

Accepted Answer

PD-1

Answer

Pembrolizumab is a PD-1 inhibitor that blocks the PD-1 receptor, preventing tumor cells from suppressing T-cell activity.

Question 5

Avelumab differs from nivolumab and pembrolizumab in that it targets:

Accepted Answer

PD-L1 on tumor cells

Answer

Avelumab is an anti-PD-L1 antibody that targets the PD-L1 ligand on tumor cells, rather than the PD-1 receptor on T cells.

Mesothelioma Therapy Practice Test