Practice Test GeeksMesothelioma Navy Practice Test
← All Mesothelioma Navy Flashcard Decks

Mesothelioma Diagnosis & Treatment Flashcards

7 cards from real Mesothelioma Navy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Mesothelioma Diagnosis & Treatment flashcards as text

  1. Which chemotherapy doublet is FDA-approved as first-line treatment for unresectable pleural mesothelioma?

    Answer: Cisplatin + pemetrexed

    The combination of cisplatin and pemetrexed (an antifolate) is the standard first-line regimen for pleural mesothelioma approved by the FDA.

  2. Before receiving pemetrexed, mesothelioma patients are given folic acid and vitamin B12. What is the primary reason for this supplementation?

    Answer: To reduce hematologic and gastrointestinal toxicity

    Folic acid and B12 supplementation significantly reduces the risk of severe neutropenia and mucositis associated with pemetrexed treatment.

  3. Which surgical procedure removes the entire lung, pleura, pericardium, and diaphragm in selected mesothelioma patients?

    Answer: Extrapleural pneumonectomy (EPP)

    Extrapleural pneumonectomy (EPP) is the most radical surgery for mesothelioma, removing the lung and all surrounding involved structures.

  4. What is the key advantage of pleurectomy/decortication (P/D) over extrapleural pneumonectomy (EPP) for mesothelioma?

    Answer: Preservation of the underlying lung with potentially lower perioperative mortality

    P/D preserves the lung, which is associated with lower operative mortality compared to EPP, while still achieving significant cytoreduction.

  5. Immunotherapy with nivolumab plus ipilimumab was approved for which mesothelioma patient population?

    Answer: Previously untreated unresectable pleural mesothelioma (first-line)

    The FDA approved nivolumab plus ipilimumab (CheckMate 743 trial) as first-line treatment for unresectable pleural mesothelioma in 2020.

  6. In the context of mesothelioma, what does 'cytoreductive surgery with HIPEC' refer to for peritoneal disease?

    Answer: Removing peritoneal tumors followed by heated intraperitoneal chemotherapy perfusion

    Cytoreductive surgery removes visible peritoneal tumor deposits, and HIPEC (hyperthermic intraperitoneal chemotherapy) then bathes the abdominal cavity in heated chemotherapy to eliminate microscopic disease.

  7. Which histological subtype of mesothelioma has the WORST prognosis and the poorest response to standard chemotherapy?

    Answer: Sarcomatoid

    Sarcomatoid mesothelioma is the most aggressive subtype, with a median survival often under 6 months and limited response to chemotherapy or surgery.