Mesothelioma Diagnosis Biomarkers and Lab Tests

Question 1

Which serum biomarker is most widely used to support a diagnosis of malignant pleural mesothelioma?

Accepted Answer

Mesothelin (SMRP)

Answer

CEA

Answer

CA 19-9

Answer

AFP

Question 2

Fibulin-3 as a mesothelioma biomarker is measured in which biological fluid?

Accepted Answer

Plasma and pleural fluid

Answer

Urine only

Answer

Cerebrospinal fluid

Answer

Sputum

Question 3

What is the clinical utility of serum SMRP levels in mesothelioma?

Accepted Answer

Monitoring disease progression and treatment response

Answer

Definitive diagnosis without biopsy

Answer

Identifying asbestos fiber type

Answer

Predicting surgical candidacy

Question 4

Which biomarker found in pleural fluid is used to differentiate malignant from benign pleural effusions?

Accepted Answer

Mesothelin

Answer

Lactate dehydrogenase (LDH)

Answer

Glucose

Answer

pH

Question 5

Elevated serum SMRP is most specific for which mesothelioma cell type?

Accepted Answer

Epithelioid

Answer

Sarcomatoid

Answer

Biphasic

Answer

Desmoplastic

Question 6

Megakaryocyte potentiating factor (MPF) is a biomarker for mesothelioma that is related to which protein?

Accepted Answer

Mesothelin

Answer

Calretinin

Answer

BAP1

Answer

Fibulin-3