Mesothelioma Diagnosis Biomarkers and Lab Tests 2

Question 1

Which laboratory finding in pleural fluid analysis is characteristic of a malignant exudative effusion?

Accepted Answer

High LDH and high protein

Answer

Low LDH and low protein

Answer

Low glucose and high amylase

Answer

Normal LDH and low pH

Question 2

Which complete blood count (CBC) finding is associated with advanced mesothelioma and poor prognosis?

Accepted Answer

Thrombocytosis

Answer

Neutropenia

Answer

Eosinophilia

Answer

Lymphocytosis

Question 3

What does an elevated serum CRP (C-reactive protein) indicate in the context of mesothelioma?

Accepted Answer

Active systemic inflammation associated with worse prognosis

Answer

Presence of sarcomatoid differentiation

Answer

Response to chemotherapy

Answer

Benign reactive pleural disease

Question 4

Hyaluronan (hyaluronic acid) levels are elevated in pleural fluid of mesothelioma patients. This is because:

Accepted Answer

Mesothelioma cells produce large amounts of hyaluronan

Answer

Bacteria in the pleural space produce it

Answer

Lung cancer metastases secrete it

Answer

It reflects liver dysfunction

Question 5

Which germline mutation significantly increases the lifetime risk of developing mesothelioma?

Accepted Answer

BAP1 mutation

Answer

BRCA1 mutation

Answer

MLH1 mutation

Answer

RB1 mutation

Question 6

What is the role of next-generation sequencing (NGS) in mesothelioma diagnosis?

Accepted Answer

Identifying actionable mutations and confirming malignancy

Answer

Measuring mesothelin expression

Answer

Assessing asbestos burden in tissue

Answer

Replacing IHC for routine diagnosis