Mental Health and Psychology Psychopharmacology 2

Question 1

What is the mechanism of action of bupropion (Wellbutrin) compared to SSRIs?

Accepted Answer

It inhibits reuptake of dopamine and norepinephrine, with no significant serotonin effect

Answer

It also inhibits serotonin reuptake like SSRIs

Answer

It is a serotonin partial agonist

Answer

It works by blocking histamine receptors

Question 2

Clozapine is an atypical antipsychotic reserved for treatment-resistant schizophrenia because it requires monitoring for:

Accepted Answer

Agranulocytosis (dangerous reduction of white blood cells)

Answer

Tardive dyskinesia

Answer

QT prolongation

Answer

Hypothyroidism

Question 3

MAOIs (Monoamine Oxidase Inhibitors) require dietary restrictions because food containing tyramine can cause:

Accepted Answer

Hypertensive crisis

Answer

Serotonin syndrome

Answer

Agranulocytosis

Answer

QTc prolongation

Question 4

Stimulant medications for ADHD (e.g., methylphenidate, amphetamines) primarily work by:

Accepted Answer

Increasing dopamine and norepinephrine availability in the prefrontal cortex

Answer

Sedating overactive neural circuits

Answer

Blocking glutamate receptors

Answer

Enhancing GABA inhibition

Question 5

What is serotonin syndrome and what combination of drugs most commonly causes it?

Accepted Answer

A life-threatening excess of serotonin; often caused by combining two serotonergic medications

Answer

A kidney disorder caused by lithium; lithium + diuretics

Answer

Sedation from combining two CNS depressants

Answer

A withdrawal syndrome from stopping SSRIs suddenly

Question 6

Naltrexone is used in addiction medicine primarily as a treatment for:

Accepted Answer

Alcohol use disorder and opioid use disorder by blocking opioid receptors

Answer

Opioid withdrawal symptoms

Answer

Cocaine dependence

Answer

Stimulant use disorder