FREE Medical Laboratory Technician Hematology and Coagulation Questions and Answers Flashcards
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In a patient with suspected heparin-induced thrombocytopenia (HIT), which laboratory finding supports the diagnosis?
Answer: Positive serotonin release assay
The serotonin release assay is the gold standard confirmatory test for HIT, detecting platelet-activating antibodies against heparin-PF4 complexes.
Which hemoglobin electrophoresis pattern is characteristic of sickle cell trait (HbAS)?
Answer: HbA greater than HbS with normal HbA2
In sickle cell trait, HbA predominates (approximately 55-60%) over HbS (approximately 35-40%) with normal HbA2 levels.
A mixing study corrects a prolonged aPTT. What does this result indicate?
Answer: Factor deficiency
Correction of a prolonged aPTT in a mixing study indicates a factor deficiency because the normal plasma supplies the missing factor.
Which cell type is the primary precursor of platelets in the bone marrow?
Answer: Megakaryocyte
Megakaryocytes are large bone marrow cells that shed cytoplasmic fragments to produce platelets.
An INR of 4.5 in a patient on warfarin therapy indicates which of the following?
Answer: Excessive anticoagulation requiring dose adjustment
An INR of 4.5 exceeds the typical therapeutic range of 2.0-3.0 and indicates excessive anticoagulation with increased bleeding risk.
What is the principle behind the erythrocyte sedimentation rate (ESR) test?
Answer: Measuring the rate at which RBCs settle in anticoagulated blood over one hour
The ESR measures how quickly red blood cells sediment in a vertical tube over one hour, reflecting the acute phase response.