FREE Medical Laboratory Technician Blood Banking and Transfusion Questions and Answers Flashcards
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A patient develops fever, flank pain, and hemoglobinuria 30 minutes after starting a red blood cell transfusion. Which type of transfusion reaction is most likely?
Answer: Acute hemolytic transfusion reaction
The triad of fever, flank pain, and hemoglobinuria shortly after transfusion onset is classic for an acute hemolytic transfusion reaction caused by ABO incompatibility.
When performing elution on antibody-coated red blood cells, which method is most effective for recovering warm-reactive IgG antibodies?
Answer: Acid elution
Acid elution methods such as the glycine-acid technique are the most effective and widely used for recovering warm-reactive IgG antibodies from red blood cells.
A patient with sickle cell disease has developed multiple alloantibodies after chronic transfusions. Which antigen matching strategy best prevents further alloimmunization?
Answer: Extended phenotype matching for Rh and Kell antigens at minimum
Extended phenotype matching for at least Rh (C, E, c, e) and Kell antigens significantly reduces alloimmunization rates in chronically transfused sickle cell patients.
Irradiation of blood components is performed to prevent which transfusion complication?
Answer: Transfusion-associated graft-versus-host disease
Irradiation inactivates donor T-lymphocytes, preventing them from engrafting and attacking the recipient's tissues in transfusion-associated graft-versus-host disease.
Which antibody is characteristically associated with a delayed hemolytic transfusion reaction occurring 7-10 days post-transfusion?
Answer: Anti-Jka
Anti-Jka is notorious for causing delayed hemolytic transfusion reactions because Kidd antibodies frequently drop below detectable levels and then exhibit an anamnestic response after re-exposure.
What is the primary purpose of performing a type and screen rather than a full crossmatch for surgical patients?
Answer: To detect clinically significant unexpected antibodies while reducing unnecessary crossmatching
A type and screen detects unexpected antibodies so that compatible blood can be rapidly provided if needed, reducing the waste of crossmatching units that may not be transfused.