Cardiovascular Disease Management Flashcards
7 cards from real MCCQE practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Cardiovascular Disease Management flashcards as text
A 55-year-old man with stable ischemic heart disease has undergone coronary angiography showing 70% mid-LAD stenosis. FFR is 0.85. What is the recommended management?
Answer: Optimal medical therapy without revascularization
FFR >0.80 indicates hemodynamically non-significant stenosis; PCI of non-flow-limiting lesions does not improve outcomes compared to optimal medical therapy (FAME trials).
Which medication is most appropriate for long-term secondary prevention in a patient with peripheral artery disease (PAD) and no history of AF or MI?
Answer: Aspirin 81 mg plus rivaroxaban 2.5 mg BID
The COMPASS trial showed aspirin 100 mg plus low-dose rivaroxaban 2.5 mg BID significantly reduces MACE and MALE in PAD patients.
A 63-year-old woman with hypertension presents with hypertensive emergency (BP 210/120, acute pulmonary edema). Which agent is most appropriate for immediate blood pressure reduction?
Answer: IV sodium nitroprusside or nicardipine
Hypertensive emergency with end-organ damage requires IV antihypertensives (nitroprusside, nicardipine, clevidipine) for controlled BP reduction by 25% in the first hour.
A 77-year-old man with severe symptomatic aortic stenosis is deemed high-risk for surgery (STS score 8%). What intervention should be recommended?
Answer: Transcatheter aortic valve implantation (TAVI)
TAVI is recommended for symptomatic severe AS patients at high or prohibitive surgical risk, with equivalent or superior outcomes to SAVR in multiple trials (PARTNER).
A 48-year-old marathon runner collapses during a race. He is found to be in ventricular fibrillation. After successful defibrillation, echocardiography shows asymmetric septal hypertrophy of 18 mm. What condition is most likely?
Answer: Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy with septal hypertrophy >15 mm and VF arrest is the most common cause of sudden cardiac death in young athletes.
A patient with New York Heart Association Class III HFrEF (EF 28%) continues to have symptoms despite ACE inhibitor, beta-blocker, MRA, and SGLT2 inhibitor. What additional therapy should be considered?
Answer: Refer for left ventricular assist device (LVAD) evaluation
Refractory advanced HF on quadruple therapy with persistent Class III–IV symptoms warrants evaluation for advanced therapies including LVAD or cardiac transplantation.
A 52-year-old man with a recent NSTEMI has LDL of 3.2 mmol/L despite maximum-dose rosuvastatin and ezetimibe. What is the next best lipid-lowering option?
Answer: Add a PCSK9 inhibitor (evolocumab or alirocumab)
PCSK9 inhibitors added to maximally tolerated statin plus ezetimibe further reduce LDL by 50–60% and reduce CV events in high-risk patients (FOURIER, ODYSSEY OUTCOMES).