LCQ LCQ Research and Evidence Base 1 — Questions and Answers
Question 1: In what year was the Leicester Cough Questionnaire first published?
- 2003 (Correct answer)
- 1998
- 2010
- 2015
Correct answer: 2003
The LCQ was first published in 2003 by Birring et al. in the European Respiratory Journal, establishing its initial validation.
Question 2: Which journal first published the original LCQ validation study?
- European Respiratory Journal (Correct answer)
- Thorax
- Lancet
- American Journal of Respiratory and Critical Care Medicine
Correct answer: European Respiratory Journal
The original LCQ validation study was published in the European Respiratory Journal in 2003.
Question 3: What was the primary finding of the original LCQ validation study?
- The LCQ demonstrated good validity, reliability, and responsiveness in chronic cough patients (Correct answer)
- The LCQ correlated poorly with objective cough counts
- The LCQ was only valid for COPD patients
- The LCQ required further development before clinical use
Correct answer: The LCQ demonstrated good validity, reliability, and responsiveness in chronic cough patients
The original 2003 validation study confirmed that the LCQ had good construct validity, internal consistency (Cronbach's alpha >0.90), and responsiveness to treatment change.
Question 4: The MCID of 1.3 points for the LCQ was established through which type of analysis?
- Anchor-based analysis using patient global ratings of change (Correct answer)
- Expert consensus only
- Normative population data
- Pharmacoeconomic modeling
Correct answer: Anchor-based analysis using patient global ratings of change
The LCQ MCID of approximately 1.3 points was determined through anchor-based analysis, where patient global impressions of change served as the external anchor.
Question 5: How many clinical studies had used the LCQ as an outcome measure as of recent literature reviews?
- Over 100 studies across multiple disease areas (Correct answer)
- Fewer than 10 studies
- Only 3 original validation studies
- LCQ has not yet been used in clinical drug trials
Correct answer: Over 100 studies across multiple disease areas
The LCQ has been used as an outcome measure in over 100 clinical studies spanning COPD, asthma, ILD, and pharmacological and behavioral treatments for chronic cough.
Question 6: Which study design provides the strongest evidence for the LCQ's responsiveness to treatment?
- Randomized controlled trials demonstrating score changes following effective treatment (Correct answer)
- Cross-sectional population surveys
- Expert opinion studies
- Retrospective chart reviews
Correct answer: Randomized controlled trials demonstrating score changes following effective treatment
RCTs that show LCQ scores improve significantly with effective treatment (compared to placebo) provide the strongest evidence of the tool's responsiveness as a clinical outcome measure.
LCQ LCQ Research and Evidence Base 1
In what year was the Leicester Cough Questionnaire first published?