LCDC Pharmacology of Addictions 2

Question 1

Which statement best distinguishes physical dependence from addiction?

Accepted Answer

Physical dependence involves withdrawal symptoms upon cessation; addiction involves compulsive use despite harm

Answer

Physical dependence always leads to addiction

Answer

Addiction requires physical dependence to be present

Answer

Physical dependence only occurs with illegal substances

Question 2

Buprenorphine is effective in treating opioid use disorder primarily because it is:

Accepted Answer

A partial agonist at mu-opioid receptors with a ceiling effect

Answer

A full agonist with a very short half-life

Answer

A complete antagonist at all opioid receptor types

Answer

An NMDA receptor blocker that reduces cravings

Question 3

Tolerance to a drug is best defined as:

Accepted Answer

The need for increasing amounts of a drug to achieve the same effect

Answer

An allergic reaction requiring dose reduction

Answer

The ability to function normally despite intoxication

Answer

A genetic predisposition to substance use disorder

Question 4

Cannabis exerts its primary psychoactive effects by binding to which receptor system?

Accepted Answer

Endocannabinoid (CB1 and CB2) receptors

Answer

Opioid receptors

Answer

Dopamine receptors

Answer

Serotonin receptors

Question 5

Compared to opioid withdrawal, alcohol and benzodiazepine withdrawal is considered more dangerous because it can cause:

Accepted Answer

Life-threatening seizures and delirium tremens

Answer

Severe diarrhea and dehydration

Answer

Extreme hypersomnia and respiratory depression

Answer

Profound hypotension requiring hospitalization

Question 6

Which of the following is an FDA-approved pharmacotherapy for treating nicotine dependence?

Accepted Answer

Varenicline (Chantix)

Answer

Naltrexone

Answer

Disulfiram

Answer

Acamprosate

Question 7

The term 'cross-tolerance' means that:

Accepted Answer

Tolerance developed to one drug reduces the effect of a pharmacologically similar drug

Answer

Two drugs administered together produce additive toxic effects

Answer

A drug is effective across multiple diagnoses

Answer

Tolerance disappears when drug use is stopped