KAPS Pharmaceutical Chemistry and Analysis 3

Question 1

Which metabolic reaction is considered a Phase I biotransformation reaction?

Accepted Answer

Oxidation via CYP450

Answer

Glucuronidation

Answer

Sulfation

Answer

Acetylation

Question 2

In UV-Vis spectroscopy, Beer-Lambert's law states that absorbance is directly proportional to:

Accepted Answer

Concentration and path length

Answer

Temperature and pressure

Answer

Wavelength and refractive index

Answer

Molecular weight and polarity

Question 3

Which functional group undergoes hydrolysis most readily under aqueous conditions, making it a common instability site in drugs?

Accepted Answer

Ester

Answer

Alkene

Answer

Ether

Answer

Alkane

Question 4

What does a positive ninhydrin test indicate in the analysis of pharmaceutical compounds?

Accepted Answer

Presence of primary or secondary amines (amino acids)

Answer

Presence of reducing sugars

Answer

Presence of aldehyde groups

Answer

Presence of phenolic hydroxyl groups

Question 5

Which parameter in chromatography is defined as the ratio of the time a solute spends in the stationary phase to the time it spends in the mobile phase?

Accepted Answer

Retention factor (k)

Answer

Selectivity factor (α)

Answer

Plate number (N)

Answer

Asymmetry factor

Question 6

Oxidative stability of a drug formulation can be improved primarily by:

Accepted Answer

Adding antioxidants such as BHA or ascorbic acid

Answer

Increasing pH above 9

Answer

Increasing storage temperature

Answer

Adding preservatives like benzalkonium chloride

Question 7

Which reaction mechanism involves simultaneous bond breaking and bond formation in a single concerted step, commonly seen in SN2 reactions?

Accepted Answer

Backside attack with inversion of configuration

Answer

Radical chain mechanism

Answer

Electrophilic addition

Answer

Nucleophilic substitution via carbocation intermediate