IBD IBD Disease Monitoring and Activity Assessment 2

Question 1

Fecal calprotectin levels greater than 250 μg/g in a clinically quiescent IBD patient most likely indicate:

Accepted Answer

Subclinical mucosal inflammation

Answer

Normal bowel function

Answer

Colorectal carcinoma

Answer

Bacterial superinfection

Question 2

Which serum antibody is most strongly associated with Crohn's disease and is used as part of serological testing in IBD workup?

Accepted Answer

ASCA (anti-Saccharomyces cerevisiae antibody)

Answer

pANCA (perinuclear anti-neutrophil cytoplasmic antibody)

Answer

Anti-dsDNA antibody

Answer

Anti-cardiolipin antibody

Question 3

Therapeutic drug monitoring (TDM) for infliximab in IBD patients primarily involves measuring:

Accepted Answer

Serum trough drug concentrations and anti-drug antibodies

Answer

Drug toxicity and hepatic metabolite levels

Answer

Stool drug excretion rates

Answer

Renal clearance of the biologic

Question 4

Which laboratory pattern is most characteristic of iron deficiency anemia due to chronic intestinal bleeding in IBD?

Accepted Answer

Low ferritin, low serum iron, and elevated TIBC

Answer

Elevated MCV with low hemoglobin

Answer

Elevated ferritin with low hemoglobin

Answer

Normal iron studies with low reticulocyte count

Question 5

Which vitamin deficiency requires specific monitoring in patients with Crohn's disease affecting the terminal ileum or following ileal resection?

Accepted Answer

Vitamin B12 (cobalamin)

Answer

Vitamin A

Answer

Vitamin C

Answer

Vitamin K

Question 6

A patient with UC on azathioprine develops a WBC of 2.1 × 10³/μL. What is the most appropriate immediate management?

Accepted Answer

Immediately discontinue azathioprine and consult hematology

Answer

Continue azathioprine and recheck CBC in 1 month

Answer

Reduce dose and add G-CSF growth factor

Answer

Switch to 6-mercaptopurine at equivalent dose

Question 7

C-reactive protein (CRP) is a more reliable marker of disease activity in which IBD type compared to the other?

Accepted Answer

Crohn's disease, particularly with ileal involvement

Answer

Ulcerative colitis only

Answer

Microscopic colitis

Answer

Indeterminate colitis only