Practice Test GeeksIBD - Inflammatory Bowel Disease Practice Test
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Knowledge Flashcards

7 cards from real IBD practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. What is the significance of the 'string sign' seen on barium follow-through in Crohn's disease?

    Answer: It represents severe luminal narrowing due to stricture or spasm

    The string sign on barium studies indicates severe narrowing of the terminal ileum from stricture or intense spasm, a classic radiologic finding in Crohn's disease.

  2. Which of the following best describes the mechanism of corticosteroid resistance in IBD?

    Answer: Overexpression of MDR1 p-glycoprotein effluxing steroids from cells

    Overexpression of MDR1 (multidrug resistance gene 1) encodes p-glycoprotein, which pumps glucocorticoids out of target cells, reducing their anti-inflammatory effect.

  3. In UC, what does the term 'backwash ileitis' describe?

    Answer: Inflammation of the terminal ileum due to reflux from a severely inflamed colon

    Backwash ileitis occurs in ~17% of pancolitis UC patients when colonic contents and inflammation 'wash back' into the terminal ileum through an incompetent ileocecal valve.

  4. Which genetic variant in the NOD2 gene confers the highest risk for Crohn's disease?

    Answer: NOD2 3020insC frameshift mutation

    The NOD2 3020insC frameshift mutation (Leu1007fsinsC) produces a truncated, nonfunctional protein and is the variant most strongly associated with ileal Crohn's disease.

  5. What is 'pouchitis' and which IBD surgery predisposes patients to it?

    Answer: Inflammation of the ileal pouch after IPAA surgery for UC

    Pouchitis is inflammation of the ileal reservoir (J-pouch) created during IPAA surgery for UC, occurring in up to 50% of patients within 10 years.

  6. Fecal calprotectin is primarily useful in IBD management for which purpose?

    Answer: Distinguishing IBD flare from IBS-like symptoms and monitoring mucosal inflammation

    Fecal calprotectin, a protein released by intestinal neutrophils, correlates with mucosal inflammation and helps distinguish active IBD from functional symptoms or IBS.

  7. Which of the following best explains why methotrexate is preferred over azathioprine for Crohn's disease in some patients?

    Answer: Methotrexate has proven efficacy for inducing remission in Crohn's; azathioprine has not

    Unlike azathioprine (used for maintenance), methotrexate has demonstrated efficacy in both inducing and maintaining remission in active Crohn's disease in clinical trials.